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Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional 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FAU - Kim, Sae Rom Kim SR AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and 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America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of 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Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Choi, Dong-Sic Choi DS AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Yoon, Yae Jin Yoon YJ AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Kim, Ji Hyun Kim JH AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Go, Gyeongyun Go G AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Nhung, Dinh Nhung D AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Hong, Kahye Hong K AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Jang, Su Chul Jang SC AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Kim, Si-Hyun Kim SH AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Park, Kyong-Su Park KS AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Kim, Oh Youn Kim OY AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Park, Hyun Taek Park HT AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Seo, Ji Hye Seo JH AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Aikawa, Elena Aikawa E AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Baj-Krzyworzeka, Monika Baj-Krzyworzeka M AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - van Balkom, Bas W M van Balkom BW AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Belting, Mattias Belting M AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Blanc, Lionel Blanc L AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Bond, Vincent Bond V AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Bongiovanni, Antonella Bongiovanni A AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Borras, Francesc E Borras FE AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Buee, Luc Buee L AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Buzas, Edit I Buzas EI AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Cheng, Lesley Cheng L AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Clayton, Aled Clayton A AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Cocucci, Emanuele Cocucci E AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Dela Cruz, Charles S Dela Cruz CS AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Desiderio, Dominic M Desiderio DM AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Di Vizio, Dolores Di Vizio D AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Ekstrom, Karin Ekstrom K AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Falcon-Perez, Juan M Falcon-Perez JM AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Gardiner, Chris Gardiner C AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Giebel, Bernd Giebel B AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Greening, David W Greening DW AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Gross, Julia Christina Gross JC AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Gupta, Dwijendra Gupta D AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Hendrix, An Hendrix A AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Hill, Andrew F Hill AF AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Hill, Michelle M Hill MM AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Nolte-'t Hoen, Esther Nolte-'t Hoen E AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Hwang, Do Won Hwang DW AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Inal, Jameel Inal J AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Jagannadham, Medicharla V Jagannadham MV AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Jayachandran, Muthuvel Jayachandran M AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Jee, Young-Koo Jee YK AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Jorgensen, Malene Jorgensen M AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Kim, Kwang Pyo Kim KP AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Kim, Yoon-Keun Kim YK AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Kislinger, Thomas Kislinger T AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Lasser, Cecilia Lasser C AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Lee, Dong Soo Lee DS AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Lee, Hakmo Lee H AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - van Leeuwen, Johannes van Leeuwen J AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Lener, Thomas Lener T AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Liu, Ming-Lin Liu ML AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Lotvall, Jan Lotvall J AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Marcilla, Antonio Marcilla A AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Mathivanan, Suresh Mathivanan S AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Moller, Andreas Moller A AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Morhayim, Jess Morhayim J AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Mullier, Francois Mullier F AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Nazarenko, Irina Nazarenko I AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Nieuwland, Rienk Nieuwland R AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Nunes, Diana N Nunes DN AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Pang, Ken Pang K AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Park, Jaesung Park J AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Patel, Tushar Patel T AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Pocsfalvi, Gabriella Pocsfalvi G AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Del Portillo, Hernando Del Portillo H AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Putz, Ulrich Putz U AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Ramirez, Marcel I Ramirez MI AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Rodrigues, Marcio L Rodrigues ML AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Roh, Tae-Young Roh TY AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Royo, Felix Royo F AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Sahoo, Susmita Sahoo S AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Schiffelers, Raymond Schiffelers R AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Sharma, Shivani Sharma S AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Siljander, Pia Siljander P AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Simpson, Richard J Simpson RJ AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Soekmadji, Carolina Soekmadji C AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Stahl, Philip Stahl P AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Stensballe, Allan Stensballe A AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Stepien, Ewa Stepien E AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Tahara, Hidetoshi Tahara H AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Trummer, Arne Trummer A AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Valadi, Hadi Valadi H AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Vella, Laura J Vella LJ AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Wai, Sun Nyunt Wai SN AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Witwer, Kenneth Witwer K AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Yanez-Mo, Maria Yanez-Mo M AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Youn, Hyewon Youn H AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Zeidler, Reinhard Zeidler R AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany. FAU - Gho, Yong Song Gho YS AD - Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Clinical Immunology, Polish-American Institute of Paediatrics, Jagiellonian University Medical College, Cracow, Poland, Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Clinical Sciences, Section of Oncology, Lund University, Lund, Sweden, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, United States of America, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy, Innovation in Vesicles and Cells for Application in Therapy, Germans Trias i Pujol Research Institute, Germans Trias i Pujol University Hospital, Badalona, Spain, Inserm, UMR837 Jean-Pierre Aubert Research Centre, Lille, France, Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary, Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, Institute of Cancer & Genetics, School of Medicine, Velindre Cancer Centre, Cardiff University, Cardiff, United Kingdom, Program in Cellular and Molecular Medicine at Boston Children's Hospital and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Section of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America, Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Cancer Biology Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Gothenburg, Sweden, Metabolomics Unit, CIC bioGUNE, CIBERehd, IKERBASQUE Research Foundation, Technology Park of Bizkaia, Derio, Bizkaia, Spain, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria, Australia, Division of Signaling and Functional Genomics, German Cancer Research Center, Heidelberg, Germany, Vice-Chancellor, Jai Prakash University, Chapra, Bihar, India, Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium, The University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia, Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Cellular and Molecular Immunology Research Centre, Faculty of Life Sciences and Computing, London Metropolitan University, London, United Kingdom, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea, Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, Department of Applied Chemistry, Kyung Hee University, Yongin, Republic of Korea, Ewha Womans University Medical Center, Seoul, Republic of Korea, Ontario Cancer Institute, Toronto, Ontario, Canada, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, Rotterdam, The Netherlands, Department of Blood Group Serology and Transfusion Medicine, University Hospital of Salzburg, Paracelsus Medical University, Salzburg, Austria, Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria, Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, Area de Parasitologia, Departamento de Biologia Celular y Parasitologia, Universitat de Valencia, Burjassot, Valencia, Spain, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia, Hematology Laboratory, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), CHU Dinant Godinne UCL Namur, Universite Catholique de Louvain, Belgium, Department of Pharmacy, NARILIS, Namur Thrombosis and Hemostasis Center (NTHC), University of Namur, Naumr, Belgium, Institute of Environmental Health Sciences and Hospital Infection Control, Medical Center-University of Freiburg, Freiburg, Germany, Department of Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands, Laboratory of Medical Genomics, AC Camargo Cancer Center, Sao Paulo, Brazil, Inflammation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia, Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea, Departments of Transplantation and Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America, Mass Spectrometry and Proteomics, Institute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy, ICREA, Barcelona Centre for International Health Research, Barcelona, Spain, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia, Laboratory of Molecular Biology of Parasites and Vectors, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Paulo de Goes Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, Centre for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, United States of Ameria, Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands, California Nanosystems Institute, University of California Los Angeles, Los Angeles, California, United States of America, Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Helsinki, Finland, Australian Prostate Cancer Research Centre-Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark, Department of Medical Physics, Jagiellonian University, Cracow, Poland, Department of Cellular and Molecular Biology, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Ludwig Institute for Cancer Research Melbourne, Austin Hospital, Heidelberg, Victoria, Australia, Department of Molecular Biology, Umea University, Umea, Sweden, Department of Molecular and Comparative Pathobiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Unidad de Investigacion, Hospital Santa Cristina, Instituto de Investigacion Sanitaria Princesa, Madrid, Spain, University of Muenchen, Department of Otorhinolaryngology and Research Group Gene Vectors, Helmholtz-Zentrum Munchen, Munich, Germany ysgho@postech.ac.kr.
MOTIVATION: Extracellular vesicles are spherical bilayered proteolipids, ...

Bioinformatics. 2014 Nov 10. pii: btu741. - Full Text - Pubmed

Positive and Negative Regulation of Th17 Cell Differentiation: Evaluating The Impact of RORC2.

Ganjalikhani Hakemi M AD - Cellular and Molecular Immunology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Ghaedi, Kamran Ghaedi K AD - Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan, Iran. FAU - Homayouni, Vida Homayouni V AD - Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Andalib, Alireza Andalib A AD - Cellular and Molecular Immunology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Hosseini, Mohsen Hosseini M AD - Department of Epidemiology, Faculty of Health, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Rezaei, Abbas Rezaei A AD - Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran ; Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
OBJECTIVE: Th17 cells are known to be involved in some types of inflammations an ...

Cell J. 2014 Fall;16(3):343-52. Epub 2014 Oct 4. - Pubmed

Effects of 60-day bed rest with and without exercise on cellular and humoral immunological parameters. LID - 10.1038/cmi.2014.106 [doi]

Hoff P AD - 1] Charite Universitatsmedizin Berlin, Department of Rheumatology and Clinical Immunology, Berlin, Germany [2] Deutsches Rheuma-Forschungszentrum (DRFZ), Berlin, Germany [3] Berlin-Brandenburg Center of Regenerative Therapies (BCRT), Berlin, Germany. FAU - Belavy, Daniel L Belavy DL AD - Charite Universitatsmedizin Berlin, Center for Muscle and Bone Research, Berlin, Germany. FAU - Huscher, Dorte Huscher D AD - 1] Charite Universitatsmedizin Berlin, Department of Rheumatology and Clinical Immunology, Berlin, Germany [2] Deutsches Rheuma-Forschungszentrum (DRFZ), Berlin, Germany. FAU - Lang, Annemarie Lang A AD - 1] Charite Universitatsmedizin Berlin, Department of Rheumatology and Clinical Immunology, Berlin, Germany [2] Deutsches Rheuma-Forschungszentrum (DRFZ), Berlin, Germany [3] Berlin-Brandenburg School of Regenerative Therapies (BSRT), Berlin, Germany. FAU - Hahne, Martin Hahne M AD - 1] Charite Universitatsmedizin Berlin, Department of Rheumatology and Clinical Immunology, Berlin, Germany [2] Deutsches Rheuma-Forschungszentrum (DRFZ), Berlin, Germany [3] Berlin-Brandenburg School of Regenerative Therapies (BSRT), Berlin, Germany. FAU - Kuhlmey, Anne-Kathrin Kuhlmey AK AD - 1] Charite Universitatsmedizin Berlin, Department of Rheumatology and Clinical Immunology, Berlin, Germany [2] Deutsches Rheuma-Forschungszentrum (DRFZ), Berlin, Germany. FAU - Maschmeyer, Patrick Maschmeyer P AD - 1] Charite Universitatsmedizin Berlin, Department of Rheumatology and Clinical Immunology, Berlin, Germany [2] Deutsches Rheuma-Forschungszentrum (DRFZ), Berlin, Germany. FAU - Armbrecht, Gabriele Armbrecht G AD - Charite Universitatsmedizin Berlin, Center for Muscle and Bone Research, Berlin, Germany. FAU - Fitzner, Rudolf Fitzner R AD - Charite Universitatsmedizin Berlin, Zentralinstitut fur Laboratoriumsmedizin und Pathobiochemie, Berlin, Germany. FAU - Perschel, Frank H Perschel FH AD - Charite Universitatsmedizin Berlin, Zentralinstitut fur Laboratoriumsmedizin und Pathobiochemie, Berlin, Germany. FAU - Gaber, Timo Gaber T AD - 1] Charite Universitatsmedizin Berlin, Department of Rheumatology and Clinical Immunology, Berlin, Germany [2] Deutsches Rheuma-Forschungszentrum (DRFZ), Berlin, Germany [3] Berlin-Brandenburg Center of Regenerative Therapies (BCRT), Berlin, Germany. FAU - Burmester, Gerd-Rudiger Burmester GR AD - Charite Universitatsmedizin Berlin, Department of Rheumatology and Clinical Immunology, Berlin, Germany. FAU - Straub, Rainer H Straub RH AD - University Hospital of Regensburg, Laboratory of Experimental Rheumatology and Neuroendocrine Immunology, Department of Internal Medicine I, Regensburg, Germany. FAU - Felsenberg, Dieter Felsenberg D AD - Charite Universitatsmedizin Berlin, Center for Muscle and Bone Research, Berlin, Germany. FAU - Buttgereit, Frank Buttgereit F AD - 1] Charite Universitatsmedizin Berlin, Department of Rheumatology and Clinical Immunology, Berlin, Germany [2] Deutsches Rheuma-Forschungszentrum (DRFZ), Berlin, Germany [3] Berlin-Brandenburg Center of Regenerative Therapies (BCRT), Berlin, Germany.
Exercise at regular intervals is assumed to have a positive effect on immune ...

Cell Mol Immunol. 2014 Nov 10. doi: 10.1038/cmi.2014.106. - Full Text - Pubmed



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