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Member since: Aug 25, 2006
From: California, United States
Status: Diagnostics & Pharmacology and Drug Discovery Moderator
My points: 59    what's this
Name: [Privacy]

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Jan 15, 2009    05:46 PM

Posted new topic in The Lighter Side of Science forum   "Dance Your Ph.D." contest

I found this contest , a challenge by the Gonzo Scientist to interpret their Ph.D. research in dance form, very interesting. A refreshing idea in the middle of other serious competitions. You can read the full Science NOW article by clicking the article title below: Dancing Scientists Invade You ...

Jan 14, 2009    09:35 PM

Abstract Human myeloproliferative diseases are common hematologic disorders characterized by clonal overproduction of maturing myeloid or erythroid cells, often caused by expression of a mutant, dysregulated tyrosine kinase (TK). These diseases can be accurately modeled in laboratory mice by the re ...

Jan 14, 2009    09:34 PM

Abstract The growth of new blood vessels, or angiogenesis, is a naturally occurring process in both health and disease states. An area of active research, regulation of angiogenesis, is being studied as an approach for the treatment of cancer and a range of other disorders having vascular prolifera ...

Jan 14, 2009    09:33 PM

Posted new protocol   A Model of Cystitis Pain in the Mouse

Abstract Interstitial cystitis (IC) is a chronic pelvic-perineal pain syndrome of unknown etiology that mainly targets the lower urinary tract. It is characterized by urinary frequency and urgency, inflammation, stiffening of the bladder wall, and visceral pain. Pain is the most prominent feature o ...

Jan 14, 2009    09:32 PM

Abstract Collagen-induced arthritis in rats is associated with inflammatory polyarthritis, sharing clinical and pathological features with those of human rheumatoid arthritis (RA). Described in this unit is a protocol for consistently inducing arthritis in female Lewis rats by immunizing them with ...

Jan 14, 2009    09:31 PM

Abstract Described in this unit is the ultrasonic distress vocalization test in rat pups. This test is a reliable method for detecting anxiolytic properties of test compounds. In this test, ultrasonic vocalizations (30 to 50 kHz) are elicited by separating rat pups of 9 to 11 days of age from their ...

Jan 14, 2009    09:29 PM

Abstract Described in this unit are radioligand binding protocols for three neuronal nicotinic acetylcholine receptor (nAChR) subtypes. Detailed descriptions of binding protocols are presented for the two predominant CNS subtypes of nAChRs, spchr('alpha', 'Math1', 'a') α4 spchr('beta', 'Ma ...

Jan 14, 2009    09:27 PM

Basic Protocol 1: Construction of a Three-Dimensional Model of Normal Human Skin Support Protocol: Inculding Specialized Substrates For Growth of Human Skin Equivalents on Basement membrane or Extracell ...

Jan 14, 2009    09:20 PM

TissueScan Cancer qPCR Array Cancer Biomarker Validation Using Archived Tumor Tissues OriGene, Inc. TissueScan is a unique qPCR array for fast and accurate gene expression profiling across a large number of cancer patient samples. High-quality cDNAs were prepared from thousands of well-docume ...

Dec 14, 2008    02:27 PM

Replied to topic in Pharmacology and Drug Discovery forum   Specific drug for GOUT?

I don't think there is ANY drug for any disease without a side-effect. As I mentioned in the summary above, side-effect wise a simplistic understanding seems to be: glucocorticoids < NSAIDS < Colchicine, i.e., glucocorticoids seem to be the best drug with minimal side-effects. Please share wit ...

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