Scientist Solutions - Viral Persistence

autobibliophile

Posted 8/28/2005 10:02:58 AM

The Sallie cycle, modulating RNA polymerase, describes how RNA viruses avoid immune surveillance and cause persistent infection.

http://www.virologyj.com/content/2/1/10
Hepatitis C (HCV), hepatitis B (HBV), the human immunodeficiency viruses (HIV), and other viruses that replicate via RNA intermediaries, cause an enormous burden of disease and premature death worldwide. These viruses circulate within infected hosts as vast populations of closely related, but genetically diverse, molecules known as "quasispecies". The mechanism(s) by which this extreme genetic and antigenic diversity is stably maintained are unclear, but are fundamental to understanding viral persistence and pathobiology. The persistence of HCV, an RNA virus, is especially problematic and HCV stability, maintained despite rapid genomic mutation, is highly paradoxical. This paper presents the hypothesis, and evidence, that viruses capable of persistent infection autoregulate replication and the likely mechanism mediating autoregulation Replicative Homeostasis is described. Replicative homeostasis causes formation of stable, but highly reactive, equilibria that drive quasispecies expansion and generates escape mutation. Replicative homeostasis explains both viral kinetics and the enigma of RNA quasispecies stability and provides a rational, mechanistic basis for all observed viral behaviours and host responses. More importantly, this paradigm has specific therapeutic implication and defines, precisely, new approaches to antiviral therapy. Replicative homeostasis may also modulate cellular gene expression.

xhz

Posted 9/6/2006 1:10:07 AM

Dear friend，

Can you tell me whether eukaryotic cell have some kind of system to destroy or exclude specificlly the intruded virus DNA and could you recommend me some related publications?

Tracy

Posted 9/9/2006 6:39:18 PM

xhz said:

Dear friend，

Can you tell me whether eukaryotic cell have some kind of system to destroy or exclude specificlly the intruded virus DNA and could you recommend me some related publications?

Double strand RNA of virus would trigger the Interferon pathway and activate PKR kinase and get degraded. At least this is one way to destroy the virus.

http://www.pnas.org/cgi/reprint/96/21/11693.pdf#search=%22PKR%20pathway%20virus%22

xhz

Posted 9/18/2006 3:04:25 AM

Tracy said:

xhz said:

Dear friend，

Can you tell me whether eukaryotic cell have some kind of system to destroy or exclude specificlly the intruded virus DNA and could you recommend me some related publications?

Thank you very much for your generous reply.