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Artificial skin model for teating of adhesion of transdermal devices

Kirils


Posted 8/6/2007 3:17:12 PM 		I need to evaluate the performance of adhesives in our transdermal products with use on sweaty skin. I cannot afford cadaver or other naturally sourced products. What artificial membranes are available for this type of product evaluation that would simulate human epidermis?

Thanks!
frasermoss


Posted 8/6/2007 3:49:47 PM 		How about going to your local butcher at acquiring some pig skin? Just make sure it is used within 48h.

It is a known method.

Alternatively I found this patent (United States Patent 5911165) describing a PVC based membrane system.

http://www.patentstorm.us/patents/5911165-fulltext.html
Kirils


Posted 8/6/2007 6:01:53 PM 		Pig skin in too inconsistant and doesn't really represent human skin very well as far as permeation goes.

If the PVC membrane is gas permeable I could attach an isotonic fluid source behind it to produce the required vapor pressure under an occlusive dressing. I will look into this PVC item ASAP. Thank you, your advise is appreciated!

K
ghunter


Posted 7/21/2008 10:38:25 AM 		what makes you believe that PVC membranes are closer to human skin?
Kirils


Posted 1/16/2009 1:44:00 PM

Kirils said:
I need to evaluate the performance of adhesivesproducts. What artificial


 


I have found the Mat Tek Epidermal to be the best along with a franz cell.  Problem is that it is too expensive.  Cadaver, pig skin and PVC is too inconsistant with their pemeation rates.  Pay a volunteer and use a microtome to get the sample. It seems to work consistantly.


A co-worker of mine is testing a semi-solid gradient system in a pressure vessle.  A patent is in the works.  His device is inexpensive, except for reagents.  I feel he has winner here.


Kirils 
Kvachhani


Posted 1/17/2009 2:11:18 AM

Hi,


How is to use adult poultry probebly broiler skin, as thickness and other parameters are mostly similar to human and easily abailable also with economicaly affordable.


Regards.

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