Edman Degradation in analyzing the protein N-terminal sequence

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Marry Leon
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Edman Degradation in analyzing the protein N-terminal sequence

Edman sequencing method analyzes the protein N-terminal sequence in sequential Edman reactions. While mass spectrometry technology has been commonly used for protein analysis, Edman sequencing is still a powerful and irreplaceable method for protein N-terminal sequencing. As a well-established sequencing method, Edman sequencing provides more accurate protein sequence data, compared to MS.