please help in dissolving ibuprofen

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eshraqa's picture
please help in dissolving ibuprofen

please i need to help me how i can dissolve ibuprofen powder to make a solution to be readt for UV analysis
it would be better if the method is without organic solvents
thank you

Dan Dwyer
Dan Dwyer's picture
Insofar as an alternative

Insofar as an alternative formulation of Ibuprofen is as a lysine salt, I would recommend raising the pH with Ammonium Hydroxide to create the ammonium salt of the ibuprofen (an acid in it's natural state).  The ammonium counter ion shouldn't interfere with subsequent analyses; especially if you don’t take the pH any higher than needed to solublize the ibuprofen.