can anyone help me with ibuprofen + paracetamol dissolution assay... i used photometric uv-vis to read my sample
Can you please be more specific as to the nature of your question about the assay?
i need to get the % dissolution assay of combined ibuprofen and paracetamol (tablet). i performed separate dissolution
1. ibuprofen 7.2 phosphate buffer, 900mL, 1hr...
2. paracetamol 5.8 phosphate buffer, 900ml, 30 mins...
the problem is everytime i'm going to read my ibuprofen (221nm) my % dissolution assay was 200+% but my paracetamol (243nm) was 100%
This sounds like a calibration problem. How did you calibration your system? That is, what solutions and concentrations did you use?
My name is Siva Prasath from India.I did M.Tech Biotechnology. Now I am doing a research work on dissolution of ibuprofen (250mg) combine with pharacetamal (500mg).I got you did some research on same field. Here I request you to send the techniques and your valuable guidance to complete my work. I want to know the buffer conce. pH and all other details, Hoping positive reply from your side.