paracetamol and ibuprofen dissolution assay

6 posts / 0 new
Last post
rnd_manda
rnd_manda's picture
paracetamol and ibuprofen dissolution assay

can anyone help me with ibuprofen + paracetamol dissolution assay... i used photometric uv-vis to read my sample

Fraser Moss
Fraser Moss's picture
Can you please be more

Can you please be more specific as to the nature of your question about the assay?

rnd_manda
rnd_manda's picture
i need to get the %

i need to get the % dissolution assay of combined ibuprofen and paracetamol (tablet). i performed separate dissolution

1. ibuprofen 7.2 phosphate buffer, 900mL, 1hr...

2. paracetamol 5.8 phosphate buffer, 900ml, 30 mins...

the problem is everytime i'm going to read my ibuprofen (221nm) my % dissolution assay was 200+% but my paracetamol (243nm) was 100%

Dr. Analytical
Dr. Analytical's picture
This sounds like a

This sounds like a calibration problem. How did you calibration your system? That is, what solutions and concentrations did you use?

sivaprasathbt
sivaprasathbt's picture
Respected Doctor,

Respected Doctor,
                        My name is Siva Prasath from India.I did M.Tech Biotechnology. Now I am doing a research work on dissolution of ibuprofen (250mg) combine with pharacetamal (500mg).I got you did some research on same field. Here I request you to send the techniques and your valuable guidance to complete my work. I want to know the buffer conce. pH and all other details, Hoping positive reply from your side.
 
 
Thanks
Siva

sivaprasathbt
sivaprasathbt's picture
Respected Doctor,

Respected Doctor,
                        My name is Siva Prasath from India.I did M.Tech Biotechnology. Now I am doing a research work on dissolution of ibuprofen (250mg) combine with pharacetamal (500mg).I got you did some research on same field. Here I request you to send the techniques and your valuable guidance to complete my work. I want to know the buffer conce. pH and all other details, Hoping positive reply from your side.
 
 
Thanks
Siva