Non-linear Regression Programs for the Analysis of Pharmacokinetic data

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Tracy
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Non-linear Regression Programs for the Analysis of Pharmacokinetic data
ramesh padodara
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what is the difference

what is the difference between 4 parameter and 5 parameter logistic analysis and what is the fifth parameter and when this analysis used. Please mention condition for using the non linear regression analysis

fcs
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The 4-parameter logistic

The 4-parameter logistic model assumes symmetry around the inflection point whereas the 5-parameter logistic takes asymmetry into account resulting in that 5th parameter.

Here is a blog post with some more details regarding the 5-parameter logistic regression model.