Anesthetics & Cortical Synchronization/Oscillations

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ecolechio
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Anesthetics & Cortical Synchronization/Oscillations

The standard protocol for surgical anesthesia in our lab is to induce with ketamine/xylazine cocktail, then maintain with inhaled isoflurane (tracheal intubation). We have done electrophysiology studies (extracellular, single-unit recordings in MI/SI/SII/various thalamic and brainstem nuclei, then PSTHs and cross-correlation analysis) in the  past using this protocol, and have had no problem from reviewers. But now I am proposing to do some recording and analysis of spontaneous cortical activity, and because I am testing a hypothesis about synchronization of spontaneous activity between homotopic body representations, I am trying to figure out whether isoflurane can induce global or widespread cortical oscillations. Any ideas??? I have been searching Google, PubMed, and anesthesiology textbooks for days with no luck...Please help!