ifenprodil

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jack_prem
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ifenprodil

Hello
I am trying to block NR2B subunits of NMDA receptors in Dentate gyrus granule cells, using ifenprodil. I add NBQX, bicuculline and then ifenprodil. Whenever I add ifenprodil (dissolved in water), I see a huge potentiation of NMDA currents (upto 100 pA increase). Could anyone has any idea what is going on?

Thanks.

James