LTP in adult rat hippocampal slices

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Salgadokg
Salgadokg's picture
LTP in adult rat hippocampal slices

 I'm trying to do LTP in slices from rats (350-450g), the slices seems to be healthy and responds very well with stimulation, but when I give the HFS (3 trains 100Hz) the post tetatinc responses are depressed, instead of being potentiated.
Does anyone know why this can be happening? I really can't get to have LTP. 

Thanks

dws123
dws123's picture
 I am not expertise in the

 I am not expertise in the field but find it very much intersting. Please refer few websites to get more knowledge on it.

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oligonucleotide synthesizer