electronic compensation when recording mEPSC

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Anastasia
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electronic compensation when recording mEPSC

 Hi, I'm new to patch clamp and will need to record some mEPSCs from neuronal cultures. I have 3 questions regarding the recording protocol:

1.) Is there a need for whole cell capacitance compensation?
2.) Is there a need for series resistance compensation?
3.) And why?

Thanks for your help.

Anastasia