Xenopus tropicalis as a spinal muscular atrophy model?

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Jon Moulton
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Xenopus tropicalis as a spinal muscular atrophy model?

Ymlahi-Ouazzani Q, J Bronchain O, Paillard E, Ballagny C, Chesneau A, Jadaud A, Mazabraud A, Pollet N. Reduced levels of survival motor neuron protein leads to aberrant motoneuron growth in a Xenopus model of muscular atrophy. Neurogenetics. 2009 Jun 11. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/19517146

Ivan Delgado
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There have been many examples of model organisms shedding some light on a given biological phenomena, only to find out that when that information is used to treat a human affliction things simply do not work as well as these studies predicted (the story of leptin research in mice comes to mind).  
As for muscle models in frogs, one must take into consideration the advantages of frog muscles. Frog muscles are pretty long, which makes it is pretty easy to isolate individual intact fibers that retain most of their mechanical characteristics, which is invaluable for multiple experiments. How much of a connection their is between muscle action in frogs as compared to humans in an open question. Yet, we all know that a lot of what we know about us has come from organisms as distant as yeast, so taking a leap (no pun intended) of faith with muscle research in frogs seems pretty reasonable to me. 
My two cents