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Touchstone42's picture

The staphylococci are important pathogenic bacteria responsible for a variety of diseases in humans and other animals. They are the most common cause of hospital acquired infection and antibiotic resistant strains MRSA have become endemic in hospitals in most countries causing major public health issues. In addition, the incidence of new strains that cause severe community-acquired infections in healthy people is increasing and MRSA strains are emerging in agricultural and domestic animals. In the race to understand staphylococcal pathogenesis the focus has been on genetics, as a bacterium can only do what its genes allow. The publication of the first staphylococcal whole genome sequence in 2001 paved the way for a greater understanding of the molecular basis of its virulence, evolution, epidemiology and drug resistance. Since then the available genomic data has mushroomed and this, coupled with the major advances in genetic know-how and the availability of better genetic tools, has allowed significant advances to be made.

from Jodi Lindsay in Staphylococcus: Molecular Genetics

vikrant's picture
MRSA leading to Macrolide

MRSA leading to Macrolide resistance cases are seen increasing.Clindamycin , a macrolide, is frequently used in skin infections caused by staphylococci. D Test (modified disk diffusion test) is being used to see resistance against Macrolides. Normally staphylococcus is sensitive to clindamycin while erytromycin is resistant. however, staphylococcal resistance to clindamycin is inducible when the bacteria is exposed to erythromycin. invitro it can be detected by placing an erythromycin disk near a clindamycin disk. if an isolate possesses inducible clindamycin resistance, the bacteria will grow around the erythromycin disk and in the area of the agar where the 2 drugs overlap. however, a zone of inhibition will be observed on the side of the clindamycin disk farther away from the erythromycn disk.