Lactic Acid Bacteria

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Touchstone42's picture
Lactic Acid Bacteria

LactobacillusLactobacillus is a genus of Gram-positive facultative anaerobic or microaerophilic bacteria. In humans they are symbiotic and are found in the gut flora. Lactobacillus species are used for the production of yogurt, cheese, sauerkraut, pickles, beer, wine, cider, kimchi, chocolate and other fermented foods, as well as animal feeds such as silage. In recent years much interest has been shown in the use of lactobacilli as probiotic organisms and their potential for disease prevention in humans and animals Lactic Acid Bacteria

Lactic Acid Bacteria with Anti-Cancer ActivitiesBeneficial bacteria include Lactobacillus and Bifidobacterium spp. and other lactic acid bacteria (LAB) commonly known as probiotics. LAB possesses numerous potential therapeutic properties including anti-inflammatory and anti-cancer activities and other features of interest. In recent years, studies with in vitro cell culture and animal models that clearly demonstrated protective effects of LAB for anti-tumor and anti-cancer effects. Dietary administration of LAB alleviated the risks of certain types of cancers and suppressed colonic tumor incidence, volume and multiplicity induced by various carcinogens in different animal models. Oral administration of LAB effectively reduced DNA adduct formation, ameliorated DNA damage and prevented putative preneoplastic lesions such as aberrant crypt foci induced by chemical carcinogens in the gastrointestinal (GI) tract of various animal models. LAB also increased the latency period and survival rates in test animals when challenged with carcinogenic agents. Reports also indicated that LAB cultures administered to animals inhibited liver, colon, bladder and mammary tumors, highlighting potential systemic effects of probiotics with anti-neoplastic activities Lactic Acid Bacteria

Medicinal Uses of Lactic Acid BacteriaMost probiotic strains belong to the genus Lactobacillus. The promising results of a first generation of probiotic microbes, evaluated in animal models as well as natural infections in animals and humans indicate a promising future for coming generations of probiotics. Antibiotic-associated, travellers' and pediatric diarrhea have been most studied, and more recently, inflammatory bowel disease and irritable bowel syndrome. Probably future probiotics will contain mixes of strains with complementary characteristics, tailormade for different gastrointestinal diseases, vaginosis or as delivery systems for vaccines, immunoglobulins and other protein based therapies Lactic Acid Bacteria

Exopolysaccharide Formation by Lactic Acid BacteriaLactic acid bacteria (LAB) synthesise a wide variety of exopolysaccharides (EPS); these polysaccharides are synthesised extracellularly from sucrose by glycansucrases, or intracellularly by glycosyltransferases from sugar nucleotide precursors. Biofilm formation, stress resistance and sucrose utilisation are clearly linked to the formation of EPS in individual species of LAB. The high frequency of homopolysacharide (HoPS) and heteropolysaccharide (HePS) producing LAB in the oral cavity and intestinal ecosystems argues in favour for an important role of EPS formation for the persistence of LAB in these habitats. The intricate regulatory network controlling the expression of glycansucrases in oral streptococci is in keeping with the contribution of HoPS and extracellular glycansucrases to biofilm formation and persistence in the oral cavity. EPS production by intestinal lactobacilli may play a comparable role. Glycansucrases in Lb. reuteri of HoPS and FOS production are regulated in response to stress sensed by the cytoplasmic membrane. The products of glycansucrases improve survival of lactobacilli in a scenario characterised by strong fluctuations in water activity, temperature, pH, and nutrient supply, and the presence of natural inhibitors. Because the expression of glycansucrases in many strains of lactobacilli and Leuconostoc species is induced by sucrose, the contribution of glycansucrases to sucrose catabolism may be their main ecological role in some strains Lactic Acid Bacteria

varsha's picture
Hi touchstone.

Hi touchstone.
Interesting write-up on lactic acid bugs (If it is not your own, please cite the appropriate reference and give credit to the authors).
Is there information on why these gut bacteria do not cause an immune response in the gut?