Description: Specifically, the project will involve molecular, biochemical, and cellular approach, utilizing newly developed innovative Apc gene-knockout ‘Min’ mouse in vitro and in vivo models to (1) investigate how mutation in Apc gene promotes mammary tumor formation and (2) evaluate the mechanistic efficacy of chemo-preventive dietary agent Curcumin. The study will focus on cellular and molecular changes of ENU-induced mammary carcinogenesis and prevention by Curcumin. Genomic and Proteomic approaches will be utilized to identify the target molecular markers and signal transduction pathways of carcinogenic transformation and its prevention. Outcome of this study will identify/validate the role of adenomatous polyposis coli (APC) gene in breast cancer progression, and represent novel approach to study the molecular and biological manifestations of gene-environment and gene-nutrition interactions impacting breast carcinogenesis and prevention with strong clinical relevance.
Duties and Responsibilities
The successful candidate will:
- Develop a comprehensive understanding of the relevant scientific literature
- Study cell signaling, flow cytometry, western blotting and immunohistochemistry
- Generate hypotheses and experimental plans for in vitro and in vivo models
- Prepare figures and manuscripts for publications
- Work and supervise junior members of the team (undergraduate and graduate students).
Highly motivated candidates with strong work ethic and excellent written and presentation skills are encouraged to apply. The successful candidate must:
- Possess a PhD or MD with in vitro, in vivo, protein biochemistry, molecular and cellular biology experience
- Have a strong publication record
- Have hands-on experience with cell culture, in vitro cell-based assays, immunofluorescence assays, real time-PCR, Western blot, hypothesis generation and experimental planning, performing in vitro and in vivo models of cancer, the study of cell signaling, flow cytometry, and immunohistochemistry
- Be fluent in English and possess outstanding interpersonal skills, a high level of energy and initiative, good organizational skills, and have the flexibility to adapt to changing needs and priorities.
How to Apply
Review of applications will begin immediately and will continue until the position is filled. The compensation package will be commensurate with experience. Interested candidates should submit their curriculum vita, personal contact information, and three professional recommendation letters electronically to e-mail: anna.eckhardt [at] hamptonu [.] edu. The recommendation letters should be addressed to:
Meena Katdare, PhD
Professor & Scientific Director
Hampton University Skin of Color Research Institute
P.O. Box 6035
Hampton, VA 23668
Department of Dermatology
Eastern Virginia Medical School
Norfolk, VA 23507