Postdoctoral Research Fellow
University of Edinburgh - Department of Biological Sciences
Our lab is interested in understanding lineage choices of pluripotent cells We would like to know why seemingly homogenous populations of ES cells generate mixtures of cells of different lineages, even when all cells in the starting population are exposed to the same environment.
We have recently completed a screen designed to identify markers that predict how an individual cell will respond to a particular differentiation environment.
This project will exploit these markers for understanding the mechanisms that drive and consolidate lineage choice, and for devising strategies to better control differentiation throughout a population.
We will also explore the implications of these findings for normal embryonic development. This position is funded for 2.5 years by the BBSRC.
Cell culture, preferably experience growing and differentiating mouse embryonic stem cells. Molecular biology, generation of genetically modified cell lines, Immunocytochemistry, FACS analysis, qPCR, image analysis. Experience of working with early mammilian embryos would also be helpful.
Fixed Term: for 2 years 6 months
Closing Date: 6 June 2011