Postdoctoral Fellow - Haematological Cancers

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Amar Annamalai
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Postdoctoral Fellow - Haematological Cancers

Postdoctoral Fellow - Haematological Cancers : Cambridge, United Kingdom

Postdoctoral Fellow – Haematological Cancers
Salary range: £30202 to £37860 dependent on experience
Fixed-term for 2.5 years
A postdoctoral Fellow post is available for a motivated and talented scientist interested in the mechanistic role of specific cancer gene mutations in the pathogenesis of haematological malignancies with the ultimate goal of identifying new, targeted treatments. The research will focus on poor-prognosis myeloid and lymphoid malignancies for which novel treatments are urgently needed e.g. see Refs 1, 2.

The successful applicant will determine the impact of cancer gene mutations in haematopoiesis and leukaemia development using established murine models. Syngeneic transplantation of haematopoietic cells from these models, modified by retroviral transduction or CRISPR/Cas9 technology, will be performed to assess the impact of additional mutations on disease phenotype. In parallel, CRISPR/Cas9 technology will be used to generate specific cancer gene mutations in human cell lines for in vitro studies. Engineered lines will be used to gain mechanistic insight into the function of cancer gene alterations using diverse approaches e.g. deep sequencing, biochemistry and molecular/cellular biology techniques. Potential therapeutic targets will be identified using large-scale drug and CRISPR/Cas9 screening approaches. There will be an opportunity to explore novel immunotherapy strategies using genetically modified murine strains.

The Fellow will report to Dr Chi Wong, affiliated with Dr David Adams’ Experimental Cancer Genetics group in the Wellcome Trust Sanger Institute in Hinxton, near Cambridge, UK.

References

1. Wong, C. C. et al. Inactivating CUX1 mutations promote tumorigenesis. Nat. Genet. 46, 33–38 (2014).
2. Ramsay, A. J. et al. POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia. Nat. Genet. 45, 526–530 (2013).

Essential Skills

• PhD in a relevant biological science e.g. murine cancer or haematopoiesis models
• Previous experience in working with murine models
• Expertise in multi-colour flow cytometry
• In vitro cell culture
• Familiarity with general molecular biology, biochemistry and cell biology techniques
• Ability to work both independently and within a team
• Good spoken and written English
• Ability to communicate effectively with collaborators and at group/external meetings

Ideal Skills

• Retrovirus/lentivirus generation to infect haematopoietic cells
• Knowledge or experience of gene targeting or CRISPR/Cas9 technologies

Other information

Postdoctoral Fellows are typically in their first or second postdoctoral position as part of a period of early career research training. Due to the nature of the contract no minimum or maximum period of employment can be guaranteed.

Life at the Sanger

The Genome Campus is a 100-acre estate south of Cambridge in the grounds of Hinxton Hall. Nestled in the quiet countryside of these landscaped gardens, are two world-class research facilities: the Wellcome Trust Sanger Institute and the European Bioinformatics Institute (EBI). The site has become the British hub of biomedical science. The Campus is also home to the Wellcome Trust Advanced Courses and Scientific Conferences programme and the Wellcome Trust Conference Centre.
In addition to its peaceful location the campus offers excellent facilities including a state of the art data centre, gym, two cafes, a nursery, dining facilities, a cycle to work scheme, car sharing and free campus buses from various locations around Cambridge.

Equally important to campus life is the range of social activities offered by the Sports and Social Club whether it is a Burns' Night Supper or a quiz night there are opportunities to meet with people working across the organization.

Learning, development and networking are other important aspects of life on campus. There are a range of scientific seminars with our own and invited speakers, scientific group meetings and skills development workshops.

Please include a covering letter and CV with your application.
Closing date for applications: 7th May 2015

kgbiotech1980
kgbiotech1980's picture
 

 

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mso-bidi-font-weight:bold">Dear Sir,
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font-family:"Times New Roman","serif";background:#FEFEFE">It is my great pleasure to have a chance to write to you. My name is Krishan Gopal Jain and I am writing this letter to
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#FEFEFE">the Postdoctoral position.  I got Ph.D. degree in Stem Cell and Tissue Engineering in July 2013 from All India Institute of Medical Sciences, New Delhi, India.  At present I am working as Associate professor of Zoology in Aakash Educational Services, India.
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line-height:115%;font-family:"Times New Roman","serif";background:#FEFEFE">My thesis work was focused on the development of effective bone graft alternative for bone tissue engineering utilizing biocomposite scaffolds and regenerative and osteogenic properties of mesenchymal stem cells. Over the years, I have developed a good tissue culture and molecular biology skills.
background:#FEFEFE">I have an acumen of culturing cells from various tissue sources which spans isolation and expansion of stem cells from Rat and human bone marrow, from human dental pulp, umblical cord, limbal ring, trabecular bone and cartilage.
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"Times New Roman","serif";mso-fareast-font-family:"Times New Roman"">Besides this, I assisted in organizing meetings, SOP development, patient counseling, store purchase, equipment maintenance and lab administration.

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background:#FEFEFE">Being well aware of your outstanding academic accomplishments, I would greatly appreciate it if you could provide me with an opportunity to continue my research as post-doctoral fellow under your supervision. I believe that my research activities and skills will be suitable for your research field and also the experience in your group will be able to provide necessary opportunities for my research careers. This position will allow me pursue research in field of my interest and also to apply my skills.
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font-family:"Times New Roman","serif";background:#FEFEFE">Thank you very much for your consideration and looking forward to hearing from you.

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Sincerely,

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