Postdoc position to study Biochemistry of HIV-1 at Albert Einstein College

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test1242
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Postdoc position to study Biochemistry of HIV-1 at Albert Einstein College

Highly motivated, driven, and talented postdoctoral fellows are sought to join studies on the anti-HIV-1 protein TRIM5-alpha and the uncoating process of HIV-1. The selected individuals will join a fast-pace environment and will have the opportunity to learn about the current challenges of the HIV-1/AIDS field. The laboratory is located in the new Price Center Building, a recently constructed state-of-the-art biomedical research facility centrally located on the campus of the Albert Einstein College of Medicine, Bronx, NY. Funding is currently available for up to 3 years, with the possibility of further extensions.

Position 1: Biochemistry of HIV-1 Uncoating.
The aim of this project is to define biochemically the process of viral uncoating and reverse transcription, using as a model HIV-1 and MLV retroviruses.

Requirements:
 
1) Recently obtained PhD or MD degree;
2) Strong background on biochemistry, particularly protein fractionation by ultracentrifugation using gradients;
3) Experience in molecular biology specifically cloning, aSouthern blot analysis nd the use of real-time PCR;
4) Cell biology techniques, including DNA transfection, cell culture and creation of stable cell lines;
5) Experience using a flow cytometer and flow data analysis.
6) Two first-author publications.
 
Position 2: Structure-function Studies of the anti-HIV-1 protein TRIM5

The aim of this program is to gain structural understanding of the restriction factors TRIM5-alpha and TRIMCyp. Collaborations are undergoing with members of the Protein Structure center at the Albert Einstein College of Medicine and the New York Structural Biology Center.

Requirements:
 
1) Recently obtained PhD or MD degree;
2) Experience in molecular biology techniques, including cloning and western blotting;
3) Experience in protein purification using different tags;
4) Experience using an FPLC with different type of columns;
5) Experience on protein expression in different systems, including bacteria, insect (baculovirus) and mammalian cells;
6) Two first-author publications.
 
All applicants should have excellent communication skills. Einstein is an equal opportunity/affirmative action employer. Please provide a CV, and the name of three references by email to Felipe Diaz-Griffero Ph.D. (felipe.diaz-griffero@einstein.yu.edu).