Postdoc Position

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Amar Annamalai
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Postdoc Position

Postdoc Position "Formation And Regulation Of Microtubules" : Heidelberg, Germany

Postdoc position: “Formation and Regulation of Microtubules”
Centre for Molecular Biology (ZMBH)
University of Heidelberg

gamma-tubulin is a highly conserved member of the tubulin family that is involved in the formation of microtubules, the fibres that segregate the chromosomes in mitosis 1. gamma-tubulin assembles together with other proteins into larger complexes. We were the first who discovered binding partners of gamma-tubulin 2,3 and who could show that gamma-tubulin complexes are recruited by receptors to the centrosome 4-7. Recently, we showed that GTP binding to yeast gamma-tubulin is essential for microtubule formation 8 and that phosphorylation of the receptor Spc110 by Cdk1 regulates gamma-tubulin complex oligomerization and microtubule formation.

In this project, we will investigate the function of human and yeast gamma-tubulin complexes using cell biology, total internal reflection (TIRF) microscopy and electron microscopy.

The group of E. Schiebel (http://www.zmbh.uni-heidelberg.de/ schiebel/default.shtml) is looking for a highly motivated postdoc with a strong background in cell biology, biochemistry, TIRF microscopy or single molecule measurements. The successful candidate will be part of an international, highly motivated team of PhD students and postdocs that works at the forefront of scientific research.

The postdoc position (E13) is funded for 3 years.

Time period: April 2015 – March 2018
Please send applications to E. Schiebel (schiebel.elmar@zmbh.uni-heidelberg.de).
Selected publications to this topic by the Schiebel group:
1 Pereira, G. & Schiebel, E. Centrosome-microtubule nucleation. J. Cell Sci. 110, 295-300 (1997).

2 Geissler, S. et al. The spindle pole body component Spc98p interacts with the γ-tubulin-like Tub4p of Saccharomyces cerevisiae at the sites of microtubule attachment. EMBO J 15, 3899-3911 (1996).

3 Knop, M., Pereira, G., Geissler, S., Grein, K. & Schiebel, E. The spindle pole body component Spc97p interacts with the γ-tubulin of Saccharomyces cerevisiae and functions in microtubule organization and spindle pole body duplication. EMBO J 16, 1550-1564 (1997).

4 Knop, M. & Schiebel, E. Spc98p and Spc97p of the yeast γ-tubulin complex mediate binding to the spindle pole body via their interaction with Spc110p. EMBO J 16, 6985-6995 (1997).

5 Knop, M. & Schiebel, E. Receptors determine the cellular localization of a γ-tubulin complex and thereby the site of microtubule formation. EMBO J 17, 3952-3967 (1998).

6 Erlemann, S. et al. An extended γ-tubulin ring functions as a stable platform in microtubule nucleation. J. Cell Biol. 197, 59-74, doi:jcb.201111123 [pii]10.1083/jcb.201111123 (2012).

7 Lin, T. C. et al. Cell-cycle dependent phosphorylation of yeast pericentrin regulates gamma-TuSC-mediated microtubule nucleation. Elife 3, e02208, doi:10.7554/eLife.02208 (2014).

8 Gombos, L. et al. GTP regulates the microtubule nucleation activity of gamma-tubulin. Nat. Cell Biol. 15, 1317-1327, doi:ncb2863 [pii]10.1038/ncb2863 (2013).

Job details

Employer
Universitat Heidelberg
Website
http://www.uni-heidelberg.de
Location
  • Im Neuenheimer Feld 282, Heidelberg, Baden-Wrttemberg, Germany
Posted
2 days ago
Expires
April 03, 2015
Job type
Postdoctoral
Salary
Unspecified
Qualifications
Postgraduate - Doctorate/PhD
Employment type
Contract
Job hours
Full-time