Postdoc Fellowship in apoptosis/ cell signaling at Karolinska Institutet, S

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Postdoc Fellowship in apoptosis/ cell signaling at Karolinska Institutet, S

Apoptosis is a highly regulated process of cell deletion and plays a fundamental role in tissue homeostasis. The removal of apoptotic cell debris by macrophages is termed programmed cell clearance and plays a crucial role in the resolution of inflammation. The current project will utilize in vitro systems and in vivo (mouse) models of relevant human diseases to study the role of macrophage engulfment of apoptotic cells in chronic inflammation and autoimmune disease. Improved understanding of the fundamental signaling pathways involved in programmed cell clearance will aid in the development of novel therapeutic interventions in chronic inflammation and autoimmune conditions.
 
The successful applicant will work at the Division of Molecular Toxicology (Head: Bengt Fadeel) at the Institute of Environmental Medicine. He/She will study the molecular signaling underlying apoptotic cell recognition and engulfment by macrophages and will utilize animal models for the assessment of the in vivo significance of these signaling pathways in disease. The project is funded by the Swedish Research Council and also involves collaborations with a number of other research groups at the national and international level.
 
Qualifications: We are looking for highly motivated candidates with a PhD degree in cell biology or immunology or equivalent field of research and a strong interest in apoptosis and cell signaling. Experience with the following techniques is needed: primary cell cultures and co-cultures, cell death (apoptosis/necrosis) assays, confocal and light microscopy (phagocytosis assays), flow cytometry. Excellent communication skills and an ability to interact socially and scientifically with other post docs and students in the laboratory are essential. Previous post doc experience and a strong publication record are preferred.
 
Applicants who have completed their degree no more than three years before the last date for applications should be given priority. Candidates who have completed their degree earlier than this should receive equal priority if special grounds exist.
 
Contactpersons:
 
Prof. Bengt Fadeel, M.D., Ph.D (bengt.fadeel@ki.se)
Union representatives are Ulla Stenius, SACO (ulla.stenius@ki.se) and Christina Trossvik, OFR/ST (christina.trossvik@ki.se)
 
Application procedure:
 
Please send your application to eval(unescape('%64%6f%63%75%6d%65%6e%74%2e%77%72%69%74%65%28%27%3c%61%20%68%72%65%66%3d%22%6d%61%69%6c%74%6f%3a%72%65%67%69%73%74%72%61%74%6f%72%40%69%6d%6d%2e%6b%69%2e%73%65%22%3e%72%65%67%69%73%74%72%61%74%6f%72%40%69%6d%6d%2e%6b%69%2e%73%65%3c%2f%61%3e%27%29%3b')), to reach us by no later than November 26th, 2010, marked with reference number 5976/2010 including the following documents in pdf:
 
* • CV including date of public thesis defense and previous positions
* • complete list of publications
* • short statement of research interests (maximum 1 page)
* • signed letters of reference from at least two references (note: mandatory)
 
Karolinska Institutet is one of the world´s leading medical universities. Its mission is to contribute to the improvement of human health through research and education. Karolinska Institutet accounts for over 40 per cent of the medical academic research conducted in Sweden and offers the country´s broadest range of education in medicine and health sciences. Since 1901 the Nobel Assembly at Karolinska Institutet has selected the Nobel laureates in Physiology or Medicine.
 
The Institute of Environmental Medicine, a department at Karolinska Institutet, is an interdisciplinary research organization within the field of Environmental Medicine. The purpose is to carry out research and education, and perform investigations and analyses, pertaining to physical and chemical aspects of environmental medicine and health protection.