POST- DOCTORAL POSITION AVALIABLE – FAPESP – Brazil Area of expertise: Cell and Molecular BiologyUnit/ Institution: CCBS/UFSCARLinked to the thematic project entitled: The extracellular matrix in aging, exercise and in the tumor microenvironmentCoordinator of the thematic project: Dr. Heloisa Sobreiro Selistre-de-AraujoSubproject: Plasticity and remodeling of articular cartilage in aging and strength training in humans.Lead researcher: Dra. Stela Márcia MattielloVacancies: 01Duration: 4 monthsScholarship value: R$ 6.819,30 (approximately U$ 2,200.00)Summary: Osteoarthritis (OA) is the most common joint disease in the world among adults. It is characterized by degeneration or progressive destruction of articular cartilage. The cartilage has the chondrocyte as the main cellular component, which is surrounded by the extracellular matrix. This cell has receptors that respond to mechanical stress, adapting itself to the stimulus received. The chondrocytes are also responsible for the metabolic balance between the anabolic and catabolic activities of the tissue while maintaining its structure and functional integrity. The presence of inflammation in joints affected by osteoarthritis has been investigated by the presence of local and circulating cytokines. The multifactorial etiology of OA points to obesity as one of the main risk factors, especially regarding the presence of intramuscular adipose tissue. Thus, the investigation of the interaction of systemic biological mediators between obese individuals and individuals with knee OA needs to be better studied, since both are commonly present in these patients. The aging and the muscle weakness, inherent in this process, contribute to the progression of the OA. For this reason, one of the strategies for the treatment of knee OA is to do resistance exercises. There is an important concern in minimizing muscle weakness, especially in the muscles adjacent to the knee such as the quadriceps muscle. This would help to reduce mechanical stress as well as the structural changes and the joint cartilage degeneration.Requirements: The candidate must be able to assume the position immediately, to have experience in kinematic analysis, kinetic analysis, and analysis of inflammatory markers and joint cartilage metabolism. Knowledge in data processing with the softwares Qualisys Track Manager, Visual 3D, Matlab, SPSS, Hologic Discovery DXA system is desired. It is also hoped that the candidate has the motivation and ability to organize research tasks independently, accept co-supervise undergraduate and graduate students and show resourcefulness in writing reports and scientific papers in English.Candidates must send until 13/03/2017 the following documents to the e-mail Dra. Stela Márcia Mattiello (email@example.com):1) Covering letter stating the reason of interest in the fellowship with a brief account of his or her experience;2) Curriculum vitae;3) Two letters of recommendation.