Job Ref: IRC169993
Starting Salary: £27,729 - £30,486
Band Salary: £27,084 - £32,324
Applications are invited for a postdoctoral scientist position in the group of Rob Kay at the MRC Laboratory of Molecular Biology in Cambridge, UK.
The successful applicant will join a multi-disciplinary research programme aimed at understanding macropinocytosis - the process by which cells take up relatively large volumes of fluid into endoyctic vessels. Macropinocytosis is essential for immune surveillance and can be used for feeding by cancer cells and amoebae; it may also contribute to the spread of prion diseases from cell to cell. The project stems from our recent discovery that macropinocytosis is regulated by NF1, the protein mutated in neurofibromatosis. Specifically, the post-holder will investigate the processes that initiate and spatially organize macropinocytic cups around PIP3 patches; how this patch is generated; what role NF1 plays in this and how the WAVE complex is recruited to the edges, but not the middle of the PIP3 patch. Genetic screens underway in the lab will highlight further macropinocytosis regulators.
Applicants should have a PhD in a relevant biological subject, or be due to be awarded one within six months of applying. They should have laboratory-based molecular biology skills, be highly motivated, collaborative and enjoy learning new techniques, such as advanced microscopy. You will have significant input into the design and interpretation of experiments, as well as the overall direction of the project. Please refer to http://www2.mrc-lmb.cam.ac.uk/group-leaders/h-to-m/r-kay further details of the research programme.
Applications are handled by the UK Shared Business Services Ltd (UK SBS); to apply please visit our job board at http://www.topcareer.jobs/Vacancy/irc169993_4931.aspx. If you are unable to apply online please contact us on 01793 867003 quoting reference IRC169993.
Closing date: 18 December 2014
Opening For Postdoctoral Scientist – Cambridge
Job Ref: IRC169993