Presentation of the Center
The Novo Nordisk Foundation Center for Protein Research (CPR http://www.cpr.ku.dk ) at the Faculty of Health Sciences, University of Copenhagen, performs basic and applied discovery research on human proteins of biomedical relevance. The Center comprises a wide range of expertise and resources, from in silico target identification, mass spectrometry based proteomics, protein production and characterization, to elucidation of various disease mechanisms.
A Protein Production Facility will now be established at the Center, responsible for protein production of recombinant proteins in both prokaryotic and eukaryotic hosts, generating proteins samples needed for internal CPR projects and for selected strategic partners and collaborators. In addition, the facility will have expertise in protein purification techniques and biophysical characterization of the produced target proteins. The Core Protein Production Facility (PPF) will consist of 13 people (1 Head, 4 Academic Coordinators and 8 Technicians). The PPF will be structured into four teams; the Prokaryotic and Eukaryotic Teams will be responsible for all steps from the sub-cloning of target proteins and recombinant expression to purification of the target proteins using various tags. The Protein Purification Team will provide additional support in terms of classical chromatography for the purification of more challenging proteins. Finally, the Biophysics Team will provide quality control of the recombinant proteins using various biophysical techniques.
Academic Coordinator for the Prokaryotic Team
The Academic Coordinator for the Prokaryotic Team is responsible to the Head of the Protein Production Facility (PPF) and for the members of the Prokaryotic Team.
The strategic direction for PPF is set by the Head of PPF, considering scientific priorities at the Center and requirements to efficiently carry out internal and external expression projects.
The post holder will interact, and is expected to build and maintain good working relationships with staff at all levels, both internally and externally.
The Academic Coordinator will
Work with the Head of the PPF to develop the strategy and operations.
Manage the expression projects, methodologies, technologies and staff members of the Prokaryotic Team ensuring that it meets its targets and deliverables.
Run prokaryotic protein production in E. coli, compatible with generating proteins samples needed for internal CPR projects and for selected strategic partners and collaborators.
Run and optimize scale up capacity for the mg level production and purification of proteins from prokaryotic (E. coli) expression systems.
In collaboration with the Biophysics Team, provide characterization of the generated protein samples, ensuring their biological relevance and feasibility for downstream studies (quality control).
Experience and skills
Expert level experience in prokaryotic protein production with a PhD degree in the relevant area.
Expert level experience regarding protein production procedures (from sub-cloning, expression to protein purification).
Excellent scientific technology/methodology development record.
Proven troubleshooting and analytical ability, excellent attention to detail.
A track record in devising innovative scientific or technical solutions in the area of prokaryotic protein production.
Excellent communication skills, both oral and in written.
Team leadership as well as supervisory experience.
Demonstrate integrity, enthusiasm, motivation, flexibility and confidence.
Experience in protein production from Structural Biology projects.
Experience with laboratory automation.
Experience with research databases and electronic laboratory notebooks.
Employment will be in accordance with the provisions of the collective agreement between the Danish Government and AC (the Danish Confederation of Professional Associations), and the employment will be permanent as Special Consultant (37 hours per week). There is a monthly contribution to a pension fund (17.1% of the salary), and a supplement could be negotiated.
Please submit the application with the required attachments via http://jobportal.ku.dk/tap/ The Faculty of Health Sciences by clicking on "Apply online" below. Deadline for application is 7 October 2012.
The University of Copenhagen welcomes applications from suitably qualified candidates regardless of age, gender, religion or ethnic background.
For further information regarding the position please contact: eval(unescape('%64%6f%63%75%6d%65%6e%74%2e%77%72%69%74%65%28%27%3c%61%20%68%72%65%66%3d%22%6d%61%69%6c%74%6f%3a%6a%6f%62%73%40%63%70%72%2e%6b%75%2e%64%6b%22%3e%6a%6f%62%73%40%63%70%72%2e%6b%75%2e%64%6b%3c%2f%61%3e%27%29%3b'))
Deadline: 7 October 2012