Ph.D. position in Germany

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Ph.D. position in Germany

Ph.D. position in molecular biology

A Ph.D student position is available to study the regulation of alternative splicing by cellular signals in the group headed by Stefan Stamm at the University of Erlangen, Germany

The project aims to understand how cAMP dependent signals promote alternative exon inclusion in the SMN2 (survival of motor neuron 2) gene, which could be the basis to treat spinal muscular atrophy. We address this questions using a large variety of methods that range from state of the art molecular biology techniques to bioinformatics.

We are looking for a motivated, hard-working, bright and goal-oriented colleague that likes to work in a multicultural environment.

We offer excellent research facilities, a stimulating atmosphere and interesting, challenging projects that are published in leading journals. Citizens of the EU associated states in Eastern Europe and Israel are encouraged to apply, since a large amount of our funding comes from the European Union. It is possible that the laboratory will move to the United States in 2008.

More information can be found at: www.
Please indicate why you are interested in this position and by 17th September 2006 send your CV as well as the names and e-mails of three persons willing to write a letter of recommendation to eval(unescape('%64%6f%63%75%6d%65%6e%74%2e%77%72%69%74%65%28%27%3c%61%20%68%72%65%66%3d%22%6d%61%69%6c%74%6f%3a%64%6f%6d%69%6e%69%71%75%65%40%73%74%61%6d%6d%73%2d%6c%61%62%2e%6e%65%74%22%3e%64%6f%6d%69%6e%69%71%75%65%40%73%74%61%6d%6d%73%2d%6c%61%62%2e%6e%65%74%3c%2f%61%3e%27%29%3b'))

Selected references from the laboratory:

Kishore, S., and Stamm, S. (2006). The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C. Science 311, 230-232.

Rafalska, I., Zhang, Z., Benderska, N., Wolff, H., Hartmann, A. M., Brack-Werner, R., and Stamm, S. (2004). The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation. Hum Mol Genet 13, 1535-1549.

Stoilov, P., Daoud, R., Nayler, O., and Stamm, S. (2004). Human tra2-beta1 autoregulates its protein concentration by influencing alternative splicing of its pre-mRNA. Hum Mol Genet 13, 509-524.

Daoud, R., Mies, G., Smialowska, A., Oláh, L., Hossmann, K., and Stamm, S. (2002). Ischemia induces a translocation of the splicing factor tra2-beta1 and changes alternative splicing patterns in the brain. J Neurosci 22, 5889-5899.

sree sandhya
sree sandhya's picture
Respected sir,

Respected sir,

I am writing this letter to introduce myself. I am Ms. Sree Sandhya Yaramala and doing my MSc in organic chemistry in VIT (Vellore Institute of Technology) university, Vellore, Tamilnadu, India. I am currently doing my MSc project under the supervision of Prof. G. Mugesh in the Department of Inorganic and Physical Chemistry, Indian Institute of Science (IISc), Bangalore, India.
My MSc thesis work involves the Synthesis, Characterization and Antioxidant Activity of Amine- and Amide-based Glutathione Peroxidase (GPx) Mimics (organo selenium compounds). I am trying to synthesize some better GPx mimics exhibiting high antioxidant activities as compared to the existing mimics. In last summer, I have done project on Functional Mimics of Metallo-β-lactamases and I also have idea on peptide synthesis.And in BSc third year I did project on Effect of growth regulators and vermicompost on the growth of Ocimum basilicum and its oil analysis by gas chromatography. Moreover, I have little industrial experience during my BSc second year. I have also worked on Catalysis and Mechanistic Studies of Ru(III), Os(VIII), Pd(II) and Pt(IV) Metal Ions on Oxidative Conversion of Folic Acid for a short-term period.
I am highly motivated with your research work and very keen to do my PhD research in your group. I believe that I will be a productive PhD fellow in your laboratory. Also, a PhD position in your group will give me an excellent opportunity to learn some new techniques and chemistry which will be advantageous for my future career.
My long term goal is to build an academic career and continue further research in chemical biology independently. Given an opportunity, I will prove my abilities and expertise. Should you require any other information, please let me know. I eagerly look forward to your response.
With regards,

Sree Sandhya Yaramala
MSc Student –Organic Chemistry,
VIT(Vellore Institute of Technology)University,
Vellore, Tamilnadu, India.