PLEASE explain

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biovironment
biovironment's picture
PLEASE explain

could anyone please explain what does NAT2*5A stand for??
i know tht NAT2 is a gene coding for a protein but i've not been able t figure out wat stands for ' * ' followed by a number(eg 5,here) and A???
can anyone please explain...

NAT2*4 is said to be wild type......i cant understand anything :((
please....

maegmor
maegmor's picture
The sequences of genes

The sequences of genes ,coding for the same protein, show some differences among individuals. That means your NAT2 gene for example might have a cytosine as its 341. nucleotide and mine can have a thymine. Those differences are not mutations since they dont have any pathologic affect and are called polymorphisms.Even though the sequence of the NAT2 gene varies among induviduals, those variations are generally always on the same nucleotide. I mean the sequence of the NAT2 gene for example can be polymorphic on the 341. , 590. and 282. nucleotide and the rest of the sequence is the same for everyone. the most observed sequence is called the wildtype allel. And the rest are its variants even though they code for the same protein.  Those variations do not cause any diseases but have minor effects on the function of the nat2(N- acetyltransferase 2) enzyme. NAT2 plays a role in the carcinogen and drug metabolism (acetilation). Depending on which variant of the NAT2 gene people have, they are categorised as slow, intermediate or fast acetylators. People with NAT2*5 allel have a cytosine as their 341. nucleotide of NAT2 gene and people with NAT2*4 allel have thymine at the same position. NAT2*4 allel falls into intermediate and NAT2*5 allel falls into slow acetilators category. NAT2 gene is actually much more polymorphic and the examples i gave are just a part of the NAT2 allels. English is not my native language and i tried to use a nonscientific language so i hope you understand what i meant.