PhD student “Interactome of living cells in contact with nanoparticles”

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Amar Annamalai
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PhD student “Interactome of living cells in contact with nanoparticles”

PhD student “Interactome of living cells in contact with nanoparticles” : B, Belgium

Research groups VITO is a Flemish independent and customer-oriented research organization that provides innovative technological solutions, as well as scientifically based advice and support in order to stimulate sustainable development (www.vito.be). In the Applied Bio&Molecular Systems team interdisciplinary research is dedicated to develop quantitative bionanoscience for medical applications and to ensure safe design of nanotechnology. Biomina (biomedical informatics research center Antwerp) is a new interdisciplinary research unit for bioinformatics and medical informatics established by the University of Antwerp and the Antwerp University Hospital that aims to address the growing needs of biomedical data processing and to enable new interdisciplinary cross-fertilization. 
 
Description
The interdisciplinary PhD project aims to investigate the behavior and fate of engineered nanomaterials in contact with biological fluids and living cells, and consequent biological signalling responses. Emphasis is put on signalling mechanisms in immune relevant cells, underlying possible immunomodulatory effects. The nature of what is adsorbed on the nanoparticle surface is connected to the observed interactions and outcomes on cells. Both the adsorbed biomolecule corona, as well as biomarker expression signatures and pathways will be investigated and combined via a comprehensive -omics analysis and bio-informatics approach. The successful candidate is expected to: • perform research with a technological dimension on: • structural/molecular aspects of nanomaterial interactions with living cells; • cell signalling events induced by in vitro nanomaterial exposure, focusing on immune responses. These studies will be complemented with physico-chemical characterization of nanomaterials in a biological context, and data interpretation using bio-statistics and bio- informatics, and will be guided by specialists in these domains; • supervise undergraduate students on research related work. • disseminate research findings via publication, conferences, research seminars etc.
 
Additional Job Details
• Please send your CV and letter of motivation, including two reference persons with their contact details, asap to both promoters mentioned below. Registration of the scholarship application should be done on-line via the VITO website  Click Here To Apply
• The successful candidate will need to compile an application file in consultation with the promoters, and will be subjected to a verbal examination in front of a jury. Upon approval the mandate will be awarded by VITO. •
Contact: •

Promoter: Prof. dr. Kris Laukens - eval(unescape('%64%6f%63%75%6d%65%6e%74%2e%77%72%69%74%65%28%27%3c%61%20%68%72%65%66%3d%22%6d%61%69%6c%74%6f%3a%6b%72%69%73%2e%6c%61%75%6b%65%6e%73%40%75%61%6e%74%77%65%72%70%65%6e%2e%62%65%22%3e%6b%72%69%73%2e%6c%61%75%6b%65%6e%73%40%75%61%6e%74%77%65%72%70%65%6e%2e%62%65%3c%2f%61%3e%27%29%3b')) •

Co-promoter: dr. Inge Nelissen - eval(unescape('%64%6f%63%75%6d%65%6e%74%2e%77%72%69%74%65%28%27%3c%61%20%68%72%65%66%3d%22%6d%61%69%6c%74%6f%3a%49%6e%67%65%2e%6e%65%6c%69%73%73%65%6e%40%76%69%74%6f%2e%62%65%22%3e%49%6e%67%65%2e%6e%65%6c%69%73%73%65%6e%40%76%69%74%6f%2e%62%65%3c%2f%61%3e%27%29%3b')) (+32 14 33 52 11)