Who's looking @ hERG (Ether-a-go-go Related Gene)?

4 posts / 0 new
Last post
Jason King
Jason King's picture
Who's looking @ hERG (Ether-a-go-go Related Gene)?

I've just started working on hERG with a focus on its role in cancer. It would be interesting to know who else has a hERG interest and in which general direction their work is aimed.

Thanks

PM

samm
samm's picture
Hi Parvoman

Hi Parvoman
Try putting in the full profile on the "My Benchspace" section too - that should help you connect to other researchers in the same, related or complementary focus areas.
-sam

Fraser Moss
Fraser Moss's picture
I work on hERG - Check out My

I work on hERG - Check out My Benchspace for more details

I am interested in the pharmacological block of hERG by many classes of drugs that underlies acquired LQT2 syndrome.

Specifically I am trying to incorporate unnatural amino acids into the channel when they are expressed in mammalian cell lines like CHO or HEK and I am measuring the block by drugs using patch clamp electrophysiology.

My latest research was presented at the biophysical society meeting in February

Search my name at
http://www.abstractsonline.com/viewer/?mkey={F7AD318F-5F5D-4B68-A4CF-B490CC7227CE}

my poster was number 1329 and Titled:

hERG K+ Channel Drug Block Underlying Acquired Long-QT Syndrome Probed With Natural And Unnatural Amino Acid Mutagenesis In Mammalian Cells

Jason King
Jason King's picture
Thanks Frasermoss,

Thanks Frasermoss,

I had a look at the meeting abstract. Are you analysing the hERG inhibitors' interactions with hERG with the aim of designing drugs that have their main effect (anti-schizophrenia for risperidone) intact without blocking hERG and risking causing LQT?

Also, I have to give a talk on hERG in 2 weeks and I would like to give the audience (who are medical) some idea as to how hERG functions in excitable and non-excitable cells. I am trawling through the 1086 refs that PubMed throws up which start at 1995 but would be most grateful if you could recommend a few papers / reviews that you think would be useful.

Many thanks

PM