Is there an online resource with information on all orphan receptors or those orphan receptors of the TNF superfamily members? If not good review publications with this information?
Most of the studies on Orphan receptors seems to concentrate on nuclear receptors or G protein coupled receptors, I am also interested in novel TNF family members the family is up to 19 ligand members that signal through 29 receptors. I'm sure there are more ligands and receptors out there. I will keep a look out for articles on new TNF family members.
Does anyone know a good book about TNF-a pathway?
Try the "Cytokine Handbook" - its a two volume, cross referenced book on cytokines and chemokines. Also, an online resource is COPE (with cytokines!).
Here are some reviews on this subject:
1.) Blumberg and Evans
Genes and Development, Vol. 12, No. 20, pp. 3149-3155, October 15, 1998
Orphan nuclear receptorsnew ligands and new possibilities
2.) A little out-dated:
Wilson et al., 1998 Orphan G-protein-coupled receptors: the next generation of drug targets?
British J. of Pharmacology
3.) That's a newer review
Wise et al., 2004
THE IDENTIFICATION OF LIGANDS AT ORPHAN G-PROTEIN COUPLED RECEPTORS
Annual Review of Pharmacology and Toxicology 44: 43-66
Liu ZG. Related Articles, Links
Molecular mechanism of TNF signaling and beyond.
Cell Res. 2005 Jan;15(1):24-7. Review.
PMID: 15686622 [PubMed - indexed for MEDLINE]