p38 MAPK inhibitors

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Pablo DG
Pablo DG's picture
p38 MAPK inhibitors

Hi everyone... I'm looking for a p38 inhibitor for my retina cell culture. I've looked everywere and found a couple:

SB- 203580
SB- 202190
 and some other I dont remember right now

Does anyone have experience with these?... which would you recommend and why?

Thanks a lot!

tracyzh130's picture
SB 202190

SB 202190
P38 MAP(mitogen activated protein) Kinase inhibitor. SB202190 blocked p38 half maximally at 30 nM.
SB 203580
SB 203580 is a potent inhibitor of LPS-induced cytokine synthesis in the human monocyte cell line THP-1 (IC50 = 50-100 nM).