Alternative pathway???

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sharmakaushikp's picture
Alternative pathway???

Hi Friends, is there any possibility of the existence of any pathway that leads to ERK activation, but by passes Mek?

Fraser Moss
Fraser Moss's picture
Yes indeed there is. See the

Yes indeed there is. See the following papers:

1: Levin-Salomon V, Kogan K, Ahn NG, Livnah O, Engelberg D.
Isolation of intrinsically active (MEK- independent) variants of the ERK family
of map kinases.
J Biol Chem. 2008 Oct 1. [Epub ahead of print]
PMID: 18829462 [PubMed - as supplied by publisher]

2: Edelblum KL, Washington MK, Koyama T, Robine S, Baccarini M, Polk DB.
Raf protects against colitis by promoting mouse colon epithelial cell survival
through NF-kappaB.
Gastroenterology. 2008 Aug;135(2):539-51. Epub 2008 Apr 30.
PMID: 18598699 [PubMed - indexed for MEDLINE]

3: García S, López E, López-Colomé AM.
Glutamate accelerates RPE cell proliferation through ERK1/2 activation via
distinct receptor-specific mechanisms.
J Cell Biochem. 2008 May 15;104(2):377-90.
PMID: 18022816 [PubMed - indexed for MEDLINE]

4: Tapinos N, Rambukkana A.
Insights into regulation of human Schwann cell proliferation by Erk1/2 via a
MEK-independent and p56Lck-dependent pathway from leprosy bacilli.
Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9188-93. Epub 2005 Jun 20.
PMID: 15967991 [PubMed - indexed for MEDLINE]

5: Vogel S, Kubin T, von der Ahe D, Deindl E, Schaper W, Zimmermann R.
MEK hyperphosphorylation coincides with cell cycle shut down of cultured smooth
muscle cells.
J Cell Physiol. 2006 Jan;206(1):25-34. Erratum in: J Cell Physiol. 2006
PMID: 15920755 [PubMed - indexed for MEDLINE]

6: Guberman AS, Scassa ME, Cánepa ET.
Repression of 5-aminolevulinate synthase gene by the potent tumor promoter, TPA,
involves multiple signal transduction pathways.
Arch Biochem Biophys. 2005 Apr 15;436(2):285-96.
PMID: 15797241 [PubMed - indexed for MEDLINE]

7: Karanian DA, Brown QB, Makriyannis A, Bahr BA.
Blocking cannabinoid activation of FAK and ERK1/2 compromises synaptic integrity
in hippocampus.
Eur J Pharmacol. 2005 Jan 31;508(1-3):47-56. Epub 2005 Jan 7.
PMID: 15680253 [PubMed - indexed for MEDLINE]

8: Jung Kang Y, Su Jeon E, Jin Lee H, Oh YS, Suh PG, Sup Jung J, Donowitz M, Ho
Kim J.
NHERF2 increases platelet-derived growth factor-induced proliferation through
PI-3-kinase/Akt-, ERK-, and Src family kinase-dependent pathway.
Cell Signal. 2004 Jul;16(7):791-800.
PMID: 15115658 [PubMed - indexed for MEDLINE]

9: Hynds DL, Spencer ML, Andres DA, Snow DM.
Rit promotes MEK-independent neurite branching in human neuroblastoma cells.
J Cell Sci. 2003 May 15;116(Pt 10):1925-35. Epub 2003 Mar 26.
PMID: 12668729 [PubMed - indexed for MEDLINE]

10: Hanson DA, Ziegler SF.
Regulation of ionomycin-mediated granule release from rat basophil leukemia
Mol Immunol. 2002 Sep;38(16-18):1329-35.
PMID: 12217403 [PubMed - indexed for MEDLINE]

11: Kinkl N, Sahel J, Hicks D.
Alternate FGF2-ERK1/2 signaling pathways in retinal photoreceptor and glial cells
in vitro.
J Biol Chem. 2001 Nov 23;276(47):43871-8. Epub 2001 Sep 24.
PMID: 11571286 [PubMed - indexed for MEDLINE]

12: Jette C, Thorburn A.
A Raf-induced, MEK-independent signaling pathway regulates atrial natriuretic
factor gene expression in cardiac muscle cells.
FEBS Lett. 2000 Feb 4;467(1):1-6.
PMID: 10664445 [PubMed - indexed for MEDLINE]

13: Janssen RA, Veenstra KG, Jonasch P, Jonasch E, Mier JW.
Ras- and Raf-induced down-modulation of non-muscle tropomyosin are
J Biol Chem. 1998 Nov 27;273(48):32182-6.
PMID: 9822696 [PubMed - indexed for MEDLINE]

14: Greulich H, Erikson RL.
An analysis of Mek1 signaling in cell proliferation and transformation.
J Biol Chem. 1998 May 22;273(21):13280-8.
PMID: 9582373 [PubMed - indexed for MEDLINE]

15: Taha C, Tsakiridis T, McCall A, Klip A.
Glucose transporter expression in L6 muscle cells: regulation through insulin-
and stress-activated pathways.
Am J Physiol. 1997 Jul;273(1 Pt 1):E68-76.
PMID: 9252481 [PubMed - indexed for MEDLINE]

16: Grammer TC, Blenis J.
Evidence for MEK-independent pathways regulating the prolonged activation of the
ERK-MAP kinases.
Oncogene. 1997 Apr 10;14(14):1635-42.
PMID: 9135064 [PubMed - indexed for MEDLINE]

17: al-Alawi N, Rose DW, Buckmaster C, Ahn N, Rapp U, Meinkoth J, Feramisco JR.
Thyrotropin-induced mitogenesis is Ras dependent but appears to bypass the
Raf-dependent cytoplasmic kinase cascade.
Mol Cell Biol. 1995 Mar;15(3):1162-8.
PMID: 7862110 [PubMed - indexed for MEDLINE]