PhD Studentship: Chemokine receptor and their involvement in cancer cell metastasis (MUELLER_U15SF)
University of East Anglia - School of Pharmacy
14th February 2015
31st May 2015
Start Date: October 2015.
Supervisor: Dr Anja Mueller, email@example.com
Prostate cancer (PC) is the second leading cause of cancer deaths in men in America and Western Europe. The migration of cancerous cells is controlled by a number of proinflammatory macromolecules such as chemokines. Amongst others, CCR1 and CCR5 together with their ligands play an important role in prostate cancer metastasis. We therefore plan to investigate the molecular basis of receptor signal transduction in the migration of cells. We will use different prostate cancer cell lines (PC-3, LNCap, Bob), some of which have already been shown to express CCR5 and CCR1 and investigate how receptor activation regulates metastasis. We recently showed that blocking dynamin and hence blocking CCR5 internalisation completely abolishes the migration of cells. Therefore we ask what role does internalisation and arrestin-dependant signalling play in migration. Using two receptors which share endogenous ligands and are expressed on the same cell types, will further our understanding of cell migration and metastasis
Applicants should have a minimum of a 2.1 degree in MPharm, Biological Sciences, Biomedicine, Pharmacology.
This project is offered on a self-funding basis. It is open to applicants with funding or those applying to funding sources. Details of tuition fees can be found at http://www.uea.ac.uk/pgresearch/pgrfees.
A bench fee is also payable on top of the tuition fee to cover specialist equipment or laboratory costs required for the research. The amount charged annually will vary considerably depending on the nature of the project and applicants should contact the primary supervisor for further information about the fee associated with the project.
To discuss the application process or particular projects, please contact the: Admissions Office, email: firstname.lastname@example.org or telephone +44 (0)1603 591709.