Breast cancer stam cells, miR495, E12/E47, hypoxia resistance & oncogenesis

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Jon Moulton
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Breast cancer stam cells, miR495, E12/E47, hypoxia resistance & oncogenesis

Hwang-Verslues WW, Chang PH, Wei PC, Yang CY, Huang CK, Kuo WH, Shew JY, Chang KJ, Lee EY, Lee WH. miR-495 is upregulated by E12/E47 in breast cancer stem cells, and promotes oncogenesis and hypoxia resistance via downregulation of E-cadherin and REDD1. Oncogene. 2011 Jan 24. [Epub ahead of print]

c-kit
c-kit's picture
hi,

hi,
it’s not clear do they also studied the (microRNA) pheonotypic effects on the cancer stem cells?
Thanks!
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Jon Moulton
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Here's some phenotypic info

Here's some phenotypic info from the abstract (a behavioral phenotype):
"Ectopic expression of miR-495 in breast cancer cells promoted their colony formation in vitro and tumorigenesis in mice. miR-495 ... promote cell invasion and ... enhance cell proliferation in hypoxia".

Robertwe
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Particiate in breast cancer

Particiate in breast cancer (including cancer stem cells) online conference for free and in real time on January 8-11, 2013. Space is limit. About 100 international speakers. Sign up here.

linkage
linkage's picture
 oh no, oncogene again.....

 oh no, oncogene again.....