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angiocure's picture

To all cancer biologist,plz tell what is the difference between oncogene and proto-oncogene ?
thank u all

c-kit's picture

It’s too late and hopes you might be found solutions as well as might be a half-scientist by this time... :)!!

If not, then here we go:
If a gene controls the formation (of tumour) or transformation of proto-oncogenes then it’s called tumour suppressor. Now we’re in the era of stem cell biology. So if the genes inherit through their somatic genes and in proper then it can be called as somatic stem cells.

Alternatively, if the genes /proto-oncogene activates without any control (or don’t like to be silence) then it’s called oncogenes. If this genetic behaviour inherits into stem cells then it’s called as cancer stem cells.

But you know, these days you can find all these basic definitions either in any cancer papers or Google. But the point is it’s wiser to know what is the next stage and / or the complete functions of these genes. For this, here is a good paper to read: http://www.cell.com/retrieve/pii/S0092867411001279

Kindest regards
http://stemcellresources.blogspot.com/ connecting cancer and stem cell towards personalize cancer medicine

hcheung's picture
Hi angiocure,

Hi angiocure,

A proto-oncogene is the wildtype, copy-neutral, normal form of an oncogene. The proto-oncogene becomes an oncogene when its expression is increased or its protein becomes activated to contribute to cancer formation. See more on this wiki page: