Postdoctoral Fellowship Positions in Computational Biology & Molecular Biol

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Postdoctoral Fellowship Positions in Computational Biology & Molecular Biol

Postdoctoral Fellowship Positions in Computational Biology and Molecular Biology with Janet Leatherwood, PhD, and Bruce Futcher, PhD

Stony Brook University, Stony Brook, New York

Computational Biology--investigate mRNA regulatory mechanisms and circuits in the relatively simple fission yeast model system. Focus on one or more of the following: 1) determining the fundamental wiring of cell cycle transcription circuits, 2) determining how circuits and mechanisms of regulated mRNA processing (splicing, polyadenylation, turnover) act in regulating gene expression during meiosis, and 3) determining the roles of non-coding promoter associated transcripts, divergent transcription initiation, and anti-sense transcription in meiotic and cell cycle transcriptional control. Postdoctoral fellows will have opportunities for creative experimental design as well as collaborative projects and will be able to take advantage of our state of art micro-array facility(Agilent and Affymetrix), senior technical staff, high-throughput sequencing projects, and involvement in the newly founded Laufer Center for Computational Biology at Stony Brook. Expertise in math/computer science is required.

Molecular Biology—Positions are available for studies of Cell Cycle and Meiosis in yeasts Cell Cycle- dissect circuits that control transcript levels in the cell cycle with an initial focus on transcription factors, promoter occupancy, and promoter organization. How do promoter associated non-coding transcripts function in cell cycle control? How does chromatin condensation during meiosis affect polII transcription? Combining the strengths of genetics, molecular biology, and genomic analyses will be used in comparative studies of transcription circuits in the fission yeast Schizosaccharomyces pombe and budding yeast Saccharomyces cerevisiae. The postdoctoral fellow will test individual hypotheses by genetic engineering and genetic screens and will also be involved in high throughput genomic and computational approaches. (i.e. high density tiling arrays, Chip-Seq.) Positions are fully funded, come with extensive technical support, and provide a unique opportunity for advanced comparative studies in the greatly diverged fission and budding yeasts. Postdocs will be part of the Stony Brook Center for Yeast Molecular Genetics and will work closely with both PIs Janet Leatherwood and Bruce Futcher. Expertise in cell cycle, transcription mechanism, and/or yeast molecular genetics is preferred.

Meiosis determine roles of mRNA processing and stability in control of transcript levels during meiosis. Meiotic differentiation in fission yeast requires an RNA binding factor, Mei2 and works in opposition to the exosome. We have identified several early meiotic genes regulated at the level of splicing, polyadenylation, and turnover rather than by transcription initiation factors. We have also identified several mid-meiotic genes that are regulated by an anti-sense to sense transcription switches in fission yeast. Regulated splicing, RNA binding factors, and anti-sense transcription appear to be key elements during meiosis in budding yeast as well. The focus of our meiotic studies is to understand mechanisms of gene regulation at the level of RNA transcription, processing, and stability primarily in the fission yeast model system, but also including comparative studies in budding yeast. Postdocs will be part of the Stony Brook Center for Yeast Molecular Genetics. Expertise in meiosis, transcription mechanism, mRNA processing, and/or yeast molecular genetics is preferred.

To apply, please send your cover letter, C.V., and the names of three references with their email addresses and telephone numbers by e-mail to Janet Leatherwood Please include "postdoc" in the subject line of all e-mails. Candidates must hold a Ph.D. or M.D., should have less than 5 years postdoctoral experience, and have strong letters of recommendation. Details and online application are available at select category Postdoctoral. The positions are: Postdoctoral Associate, Microbiology, WC-R-5480-09-01-S, WC-R-5478-09-01-S, and WC-R-5479-09-01-S