Opening For Bioinformatician Wellcome Trust Sanger Institute

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Amar Annamalai
Amar Annamalai's picture
Opening For Bioinformatician Wellcome Trust Sanger Institute

 Seeking an experience Senior Bioinformatician to develop new computational methods to use BWT reference-free structures to rapidly genotype newly sequenced human genomes.
 
The Sequence Variation Infrastructure team is involved in some of the largest human and mouse genome sequencing projects. In the coming years, we are interested in applying novel comparative genomics representations, such as BWT based compressed storage (1), HAL representation of multiple aligned genomes (2), and scalable noSQL key-value databases to make it possible to make very fast queries across thousands of human genomes.
 
We have recently applied these technologies in proof-of-principle datasets from the 1000 genomes project (3) and are now seeking an experienced Senior Bioinformatician or programmer to further develop methods to carry out carry out tasks such as rapid genotyping of newly sequenced human genomes for known SNPs, indels, and structural variants and to analyse across large volumes of sequencing data to contribute to answering specific scientific questions.
 
This role would suit somebody with some previous exposure to bioinformatics methods development or a scientific programmers with previous experience in a high performance computing environment who wishes to gain direct knowledge of next-generation sequencing technologies and analysis.
 
The successful candidate will work closely with two established teams of analysts and developers so previous experience with next-generation sequencing data is advantageous but not strictly necessary.
 
Essential Skills
 
A M.Sc. or Phd degree in a computational science (or equivalent industry experience) 
Evidence of proficiency in computer program design and implementation in a modern programming language (e.g. Perl, Java, C, C++, Python etc.) 
Ability to quickly adapt to new problems and ideas
Excellent problem-solving skills 
Experience with managing large volumes of data
Ideal Skills
 
Experience with running software on a compute farm or cluster 
Experience of analysing data from multiple sequencing technologies 
Previous experience of developing computational methods to solve complex scientific problems
Relational or noSQL database design and manipulation 
A high level of communication skills to be able to elicit complex requirements from, and convey complex information to, groups with different levels of technical knowledge
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