Is it ethical to test out a compund on a human subject? Especially when the patient may not have completely understood the 15 page consent form. A 2007 gene therapy study ended in death, and it seems the patient wasn't aware that the therapy was not intended to have any benefit to her disease. Also, her own doctor recommended her for the trial. These are difficult questions. I know it is necessary to test the toxicity of a compound on a human subject, but the patient has to be very aware of what is going on.