please help me.any informations regrading Ceftriaxone sodium,cephradine L Arginine has any oxidation reaction and how?
these are used to manufacture antibic inj.
Ceftriaxone sodium hydrolysate can be oxidized with potassium permangenate and an acid like phosphoric acid.
You can check this reference for details on how to detect oxidized Ceftriaxone sodium.http://www.jstage.jst.go.jp/article/analsci/22/1/22_183/_article
Determination of Ceftriaxone Sodium in Pharmaceutical Formulations by Flow Injection Analysis with Acid Potassium Permanganate Chemiluminescence Detection
Deyi ZHANG1), Yongjun MA1), Min ZHOU1), Li LI1) and Hui CHEN2)
1) Institute of Chemistry, Northwest Normal University
2) Gansu Key Laboratory of Polymer Materials
(Received September 18, 2005)
(Accepted November 18, 2005)
Based on the chemiluminescence (CL) emission generated from the oxidation of ceftriaxone sodium alkali hydrolysate by potassium permanganate in polyphosphoric acid (PPA), a novel determination method for ceftriaxone sodium was developed by using a flow-injection technique. The calibration curve appears to be linear in the range between 0.05 and 100 µg mL-1 with a detection limit (3 σ) of 25 ng mL-1, and a relative standard deviation (RSD) of 0.6% for eleven replicate determinations of 5.0 µg mL-1 ceftriaxone sodium. The proposed method has been successfully utilized for the determination of ceftriaxone sodium in pharmaceutical formulations, while the chemiluminescence reaction mechanisms were investigated.