l biochemistry

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malliga
malliga's picture
l biochemistry

 
 
 Why wound healing process in diabetes mellitus delays?
which immune cells are affected  and what is the reason for the delay?

Arvind Singh Pundir
Arvind Singh Pundir's picture
Growth factors, cytokines,

Growth factors, cytokines, collagen synthesis, and many others factors involved in normal wound healing have been implicated as defective in patients with diabetes. High blood glucose can lead to defective white blood cell function and makes the wound susceptible to infection.
Proteins are the structural units of healing wounds. Collagen and proteoglycans are the important proteins in the context of wound healing (Deodhar and Rana, 1997). A lack of insulin in diabetic wounds results in more protein degradation uncoupled from protein synthesis (Marchesini et al, 1982). Collagen formation is reduced and the existing collagen lacks tensile strength (Gottrup and Andreassen, 1981). This also adversely affects fibroblast and polymorphonuclear (PMN) cell functions (Sawant, 1993).  read more from the following link
http://findarticles.com/p/articles/mi_m0MDQ/is_3_8/ai_n15656497/pg_2
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Studies of the immune cells necessary for wound healing, such as PMN leukocytes and fibroblasts, as well as studies of injured tissue suggest that there is a delayed response to injury and impaired functioning of immune cells in diabetes mellitus. There is evidence that these impairments may be the result of both an inherent (genetic) defect as well as decreased insulin availability and increased blood glucose concentration.     Rosenberg CS Nurs Clin North Am. 1990 Mar;25(1):247-61
Wound healing in the patient with diabetes mellitus.
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 or
go to the link below and download the PPT
http://www.medicaleducationonline.org/index.php?option=com_docman&task=doc_view&gid=15