GPCR tandem expression

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egovoru
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GPCR tandem expression

 Dear Colleagues,

Does anybody know any examples of expression of GPCR modules in tandem, in order to promote dimerization? I know that it works with ion channels if they have both N and C termini in the cytoplasm, but how about GPCRs? Is it possible to link two of them via some artificial (or heterologous) transmembrane helix and preserve the function? I would be very greatful for any references of this kind, and also for your own considerations.