Polyethyleneglycol (PEG) degradation ?

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Diablo
Diablo's picture
Polyethyleneglycol (PEG) degradation ?

Hi folks,

does anyone of you know how to degradate PEG ?

my prob: i've got a protein which is PEGylated @ some Aminoacids... now i want to get rid of the PEG.....

Maybe with some Enzymes who cut @ Etherbounds? (but which one, and where can i purchase them?^^)

thx for any help

Greets,
Diabloo

ghunter
ghunter's picture
Noop. There is no known

Noop. There is no known enzyme can cut it. If you are lucky and have a degradable bond between PEG and your protein, such as a disulfide linkage, you may separate the two. Otherwise, there is no chance.

Diablo
Diablo's picture
ok, thx for your answer :D

ok, thx for your answer :D

greets
diabloo