PrP antibodies specific to PrPc or PrPsc

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carmeyeii
carmeyeii's picture
PrP antibodies specific to PrPc or PrPsc

  Hi!

I have been looking the past few days for antibodies to recognize the native PrPc and PrPsc of mouse. 

So far, I think I have found some good candidates, but I am wondering if anyone here is a prion specialist and might be able to help me out with options.

I need an Ab that will recognize both PrPc and PrPsc in their native states - without denaturing or Proteinase 
K.

Also, an Ab that will recognize ONY PrPc in int native state.

And an Ab that will recognize ONY PrPsc in int native state.

I have found the following Abs:

                       PrPc   PrPsc

R2                    x           x
POM2              x           x
3F4                  x                    (will not detect mouse PrP)
AH6                 x
6H4                 x
FA31               x
15B3                            x
POM3               x
FH11                x          x    (not sure?)
F431                 x
ICSM35            x        x
ICSM18            x        x (weak)
GD11                x
GE8                  x
ICSM10           x
PrioV3             x
Mai750            x

I am not sure if all of these will detect the mouse PrP, and most of the useful ones I don't know where I could get them... Any ideas or knowledge on this topic?

Thanks very much!

C