manoclonal antibody classification

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R.K.B
R.K.B's picture
manoclonal antibody classification

Hello to all,

Is there any thing like, a monoclonal antibody can be both IgM/IgG.

Or in general, is this possible for an antibody can be both types.

Thanks in advance for your answers

Rajeev

marcus muench
marcus muench's picture
IgM and IgG are two different

IgM and IgG are two different structures. A single B-cell can switch to production of IgG rather than IgM, which is a normal function of B cells during an immune response. I believe hybridomas have been coaxed to switch isotype class as well.