...want to understand what leak current mean and why to compensate

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Hss
Hss's picture
...want to understand what leak current mean and why to compensate

 
...Hi

I would like to understand what "leak current" exactly measn; someone have some not so complicate explanation?

It will be good and nice if someone clarify too why some currents have to be compensate, for example calcium currents; sometimes this compensation is 60% or sometimes is 90%; why is better to compensate them and why can not be compensate 100%?

Thanks.

The FFM
The FFM's picture
Leak currents are those that

Leak currents are those that passively flow across the cell membrane because the channels that allow their passage are always open.

The leak channels do not gate the current like voltage or ligand activated channels,  but allow the flow of ions all the time.  There are however different types of leak channels which selectively allow the flow of particular ions (e.g. Na+ or K+) according to the electrochemical driving force and these can be regulated by a host of molecular species e.g. molecular oxygen, cyclic nucleotides, noradrenaline, serotonin and GABA.

examples of leak channels include the KCNK potassium channels and  NALCN Na+ channel,

When you ask about compensation, are you refering to the practice of "leak-subtraction"?

Hss
Hss's picture
...thanks for the answer

...thanks for the answer about leak currents, now is more clear  

 ...sorry, what I mean is the series resistence; sometimes people writte "series resistence was not compensated" and sometimes they compensated them 60% or 90%, depending of the type of cell and current; I would like to know why some currents are compensated and when they are compensated, why can not be 100%. 

Thanks.