DMSO makes patch difficult?

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lazy
lazy's picture
DMSO makes patch difficult?

 In order to eliminate the possible effect of sovent (DMSO), I prepared all solutions: for control solution, and for compound-containing solutions (always 0.2% DMSO).
Although, I can do easily patch without DMSO, I have difficulty to get a good patch with DMSO-containing external solution (control solution). 
Is this normal, or something wrong? The cell is HEK.
Thanks.