Chandelier cell

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sencajal
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Chandelier cell

Chandelier neurons or chandelier cells are a subset of GABA-ergic cortical interneurons. They are described as parvalbumin-containing and fast-spiking to distinguish them from other subtypes of GABAergic neurons. The name comes from the specific shape of their axon arbors, with the terminals forming distinct arrays called "cartridges". The cartridges are immunoreactive to an isoform of the GABA membrane transporter, GAT-1, and this serves as their identifying feature. GAT-1 is involved in the process of GABA reuptake into nerve terminals, thus helping to terminate its synaptic activity. Chandelier neurons synapse exclusively to the axon initial segment of pyramidal neurons,near the site where action potential is generated. It is believed that they provide inhibitory input to the pyramidal neurons, but there is data showing that in some circumstances the GABA from chandelier neurons could be excitatory.
In schizophrenia, scientists observe changes in their form and functionality, such as 40% decrease in the axon terminal density.

If you are interested to know more abourt chandelier cells please go through the following link. Abobe inforamtion you can find in Wikipedia (en.wikipedia.org/wiki/Chandelier_cell). Why i am particularly interested about this cell is that I stained human corical slice with parvalbumin. In that light microscopioc image i found this distict type of cell so i captured images of it and discussed with my colleagues and than only i realised  that is was a chandlier cell and imporatan in schizhophrenia and other disorders.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18816168

Fraser Moss
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sencajal

sencajal
would you mind sharing your image of the Chandelier cell that to captured here and seeing what some of the neuroanatomists on this site have to say?