Loss on drying (NAC)

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winzzz's picture
Loss on drying (NAC)


In USP : Loss on drying : Dry it at a pressure of about 50 mm of mercuric at 70 C for  4 hours: it loses not more than 1.0% of it weight

I have only hot air oven / don't have vacuum oven.
I can use hot air oven intead vacuum oven ???? 
If I can What  status  as pressure of  about 50 mm of mercuric at 70 C

help me please , thank you very much

Dr. Analytical
Dr. Analytical's picture
The drying is performed at

The drying is performed at reduced pressure so that the temperature can also be reduced.  The compound may be unstable at 100 C.  Drying in a hot air oven may not give the same result.

If you want to do a USP test, then this change would not be acceptable.