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apps's picture

I am a fresher and want to know about the calibration procedures of ESI and APCI Mass spectrometers.
Some body help me soon plz. I am waiting for your ans......

Dr. Analytical
Dr. Analytical's picture
The ESI interface does not

The ESI interface does not need calibration, but the settings are very important.

The procedures for tuning the mass spectrometer are unique for each model.  Usually it involves a special calibrant and adjusting the responses of the fragment ions until the the correct ratios and correct masses are obtained.  Each manufacturer will have information about tuning.

Analytical calibration is performed by injecting standards in the usual way.