GCMS analysis of Rapramycin

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MDCLS
MDCLS's picture
GCMS analysis of Rapramycin

Hi All I am analysing a drug eluting stent coated in Rapramycin and I doing the analysis on GCMS .I have extracted the stent in DMSO and want to do the GCMS analysis underivatised so far I can see nothing!
Any advice on the subject greatly appreciated
Regards

MDCLS

Dr. Analytical
Dr. Analytical's picture
Why are you trying to use

Why are you trying to use GCMS?  This molecule has a MW of over 900, and is not volatile.  Looking at the structure, I don't think even derivatization will help.  LC is the only real option.