how design of experiments are done for hplc method development. pleaze give the suggestions regarding which type of DOE are most suitable.
This is a very general question. If you understand DOE then you know that there are many options. I think a simple 2 level factorial design is easy if you only have tthree variables (8 experiments). I always like to add a center point so the total rimber experiments is 9.
If you have software, then you can do more complex experiments, but this is very expensive.